PL04.04 Implementing New Paradigms for Delivering Radiation Therapy in the Clinic

Although it is a pillar of cancer care, radiation therapy historically has had curative potential for minority patients and achieved cure in even fewer. Over the last few decades however, advances with concomitant systemic therapies have led to improved survival expanding indications. Definitive become standard care locally advanced lung selected early-stage cancer. New paradigms are now emerging on wave novel immunotherapy molecularly targeted therapies, as well new science accelerator physics biology. Radiation therapy, particularly stereotactic ablative radiotherapy (SABR), potentially metastatic disease setting combination therapies. Preclinical research demonstrating surprising improvements therapeutic index from ultra-high dose rate FLASH generated tremendous excitement leading initial clinical trials limited settings, next-generation technology being developed translational treatment more typical large-volume deep seated targets.